Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7825.007 | 1.0055 | 1.0072 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7825.007 | 0.9072 | 0.8759 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7825.007 | 0.8827 | 0.8424 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7825.007 | 0.6660 | 0.5307 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7825.007 | 0.5468 | 0.3444 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7825.007 | 0.2325 | -0.2342 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.00028 | uM | 9347.121 | 1.1352 | 1.1825 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 9347.121 | 0.9896 | 0.9856 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 9347.121 | 1.0741 | 1.1009 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 9347.121 | 0.9133 | 0.8789 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 9347.121 | 0.8345 | 0.7657 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.874 | uM | 9347.121 | 0.4927 | 0.2285 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 9347.121 | 0.3559 | -0.0181 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 9347.121 | 0.3290 | -0.0698 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 9347.121 | 0.3297 | -0.0684 | 1.4523 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00028 | uM | 9376.121 | 1.0344 | 1.0496 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 9376.121 | 1.0195 | 1.0282 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 9376.121 | 0.8503 | 0.7783 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 9376.121 | 0.5595 | 0.3132 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 9376.121 | 0.2491 | -0.2693 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.874 | uM | 9376.121 | 0.1121 | -0.5903 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 9376.121 | 0.0441 | -0.7916 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 9376.121 | 0.0232 | -0.8690 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 9376.121 | 0.0259 | -0.8583 | 1.3803 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7833.007 | 1.0391 | 1.0601 | 1.2952 |