Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7810.012 | 1.0472 | 1.1016 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7810.012 | 0.9968 | 0.9932 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7810.012 | 0.9358 | 0.8623 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7810.012 | 0.8075 | 0.5892 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7810.012 | 0.7411 | 0.4491 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7810.012 | 0.7893 | 0.5507 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7810.012 | 0.8109 | 0.5962 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7810.012 | 0.8002 | 0.5737 | 0.9298 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7811.036 | 0.9925 | 0.9675 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7811.036 | 0.9892 | 0.9533 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7811.036 | 1.0041 | 1.0179 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7811.036 | 1.0247 | 1.1087 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7811.036 | 0.9688 | 0.8670 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7811.036 | 0.9731 | 0.8850 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7811.036 | 0.9813 | 0.9198 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7811.036 | 0.8899 | 0.5530 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7811.036 | 0.7306 | 0.0126 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7812.036 | 1.0599 | 1.1186 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7812.036 | 1.0116 | 1.0230 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7812.036 | 1.0507 | 1.1003 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7812.036 | 0.9969 | 0.9938 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7812.036 | 0.9809 | 0.9622 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7812.036 | 0.9823 | 0.9649 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7812.036 | 0.9780 | 0.9565 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7812.036 | 0.9645 | 0.9297 | 1.0103 |