Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 1.07 | uM | 11660.144 | 0.5814 | 0.1800 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 5.33 | uM | 11660.144 | 0.5694 | 0.1562 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 26.7 | uM | 11660.144 | 0.5077 | 0.0342 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 133 | uM | 11660.144 | 0.0086 | -0.9804 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.000341 | uM | 12003.168 | 0.8893 | 0.8040 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.00171 | uM | 12003.168 | 0.9184 | 0.8558 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.00853 | uM | 12003.168 | 0.8673 | 0.7646 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.0427 | uM | 12003.168 | 0.6918 | 0.4464 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.213 | uM | 12003.168 | 0.5966 | 0.2699 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 1.07 | uM | 12003.168 | 0.5322 | 0.1485 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 5.33 | uM | 12003.168 | 0.5118 | 0.1097 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 26.7 | uM | 12003.168 | 0.4531 | -0.0030 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 133 | uM | 12003.168 | 0.0094 | -0.9671 | 1.1370 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.000341 | uM | 11939.144 | 0.9010 | 0.8772 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.00171 | uM | 11939.144 | 0.8811 | 0.8519 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.00853 | uM | 11939.144 | 0.8741 | 0.8429 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.0427 | uM | 11939.144 | 0.6796 | 0.5813 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 0.213 | uM | 11939.144 | 0.5579 | 0.4026 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 1.07 | uM | 11939.144 | 0.4515 | 0.2333 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 5.33 | uM | 11939.144 | 0.4283 | 0.1944 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 26.7 | uM | 11939.144 | 0.3591 | 0.0729 | 1.6446 | |
| ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 133 | uM | 11939.144 | 0.3976 | 0.1414 | 1.6446 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9047.121 | 0.9761 | 0.9400 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9047.121 | 0.8657 | 0.6681 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9047.121 | 0.9032 | 0.7596 | 0.7949 |