Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9047.121 | 0.8632 | 0.6622 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 0.175 | uM | 9047.121 | 0.7723 | 0.4451 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 0.874 | uM | 9047.121 | 0.4302 | -0.3078 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 4.37 | uM | 9047.121 | 0.3166 | -0.5293 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 21.8 | uM | 9047.121 | 0.3747 | -0.4182 | 0.7949 | |
| 184A1 | NM | Basal | Topotecan | TOP1 | TOP | 109 | uM | 9047.121 | 0.3219 | -0.5195 | 0.7949 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9095.121 | 1.0025 | 1.0041 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9095.121 | 0.8761 | 0.7911 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9095.121 | 0.8999 | 0.8316 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9095.121 | 0.7087 | 0.5008 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 0.175 | uM | 9095.121 | 0.6537 | 0.4031 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 0.874 | uM | 9095.121 | 0.4795 | 0.0835 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 4.37 | uM | 9095.121 | 0.1866 | -0.5068 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 21.8 | uM | 9095.121 | 0.0804 | -0.7556 | 1.1992 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 109 | uM | 9095.121 | 0.0512 | -0.8323 | 1.1992 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7793.007 | 0.9681 | 0.9536 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7793.007 | 0.9742 | 0.9625 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7793.007 | 0.6664 | 0.4913 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7793.007 | 0.1720 | -0.4399 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7793.007 | 0.0877 | -0.6559 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7793.007 | 0.0707 | -0.7056 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7793.007 | 0.0746 | -0.6938 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7793.007 | 0.0652 | -0.7223 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7793.007 | 0.0610 | -0.7351 | 1.3832 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9035.077 | 0.9596 | 0.9658 | 2.3909 |