Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9035.077 | 1.0274 | 1.0227 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9035.077 | 0.9125 | 0.9248 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9035.077 | 0.2295 | 0.0806 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9035.077 | 0.1189 | -0.1792 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9035.077 | 0.0882 | -0.2755 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9035.077 | 0.0774 | -0.3142 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9035.077 | 0.0609 | -0.3797 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9035.077 | 0.0498 | -0.4295 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9146.121 | 1.0457 | 1.0802 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9146.121 | 0.9551 | 0.9208 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9146.121 | 0.9770 | 0.9594 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9146.121 | 0.3233 | -0.2595 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9146.121 | 0.1695 | -0.5803 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9146.121 | 0.1300 | -0.6677 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9146.121 | 0.1144 | -0.7030 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9146.121 | 0.0845 | -0.7726 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9146.121 | 0.0736 | -0.7986 | 1.1366 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 7798.077 | 1.0227 | 1.0315 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7798.077 | 1.0004 | 1.0006 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7798.077 | 1.0787 | 1.1082 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7798.077 | 0.9913 | 0.9878 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7798.077 | 0.9979 | 0.9971 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 7798.077 | 0.9250 | 0.8943 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7798.077 | 0.8166 | 0.7370 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7798.077 | 0.6970 | 0.5558 | 1.4371 |