Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7798.077 | 0.5950 | 0.3936 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9158.121 | 0.9285 | 0.8659 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9158.121 | 0.9901 | 0.9814 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9158.121 | 1.0902 | 1.1682 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9158.121 | 0.9736 | 0.9506 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9158.121 | 0.9618 | 0.9284 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9158.121 | 0.9249 | 0.8593 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9158.121 | 0.5907 | 0.2222 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9158.121 | 0.3372 | -0.2765 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9158.121 | 0.2138 | -0.5275 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9163.121 | 1.0611 | 1.2899 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9163.121 | 1.0457 | 1.2147 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9163.121 | 1.0388 | 1.1815 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9163.121 | 1.0124 | 1.0569 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9163.121 | 0.9186 | 0.6475 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9163.121 | 0.8869 | 0.5208 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9163.121 | 0.6809 | -0.1680 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9163.121 | 0.4907 | -0.6060 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9163.121 | 0.3923 | -0.7636 | 0.4382 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7801.007 | 1.0069 | 1.0214 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7801.007 | 0.9469 | 0.8377 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7801.007 | 0.8628 | 0.5906 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7801.007 | 0.8152 | 0.4568 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7801.007 | 0.6701 | 0.0747 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7801.007 | 0.6164 | -0.0559 | 0.6446 |