Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9278.121 | 0.7526 | 0.0632 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9278.121 | 0.3674 | -0.7842 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9278.121 | 0.2649 | -0.8957 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9278.121 | 0.2449 | -0.9124 | 0.4498 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9294.121 | 1.0341 | 1.0914 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9294.121 | 1.0362 | 1.0972 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9294.121 | 1.0169 | 1.0451 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9294.121 | 1.0112 | 1.0298 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9294.121 | 0.9640 | 0.9045 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9294.121 | 0.6238 | 0.0663 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9294.121 | 0.2120 | -0.7471 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9294.121 | 0.0958 | -0.9123 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9294.121 | 0.0814 | -0.9294 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9299.121 | 1.0682 | 1.3470 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9299.121 | 1.0008 | 1.0037 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9299.121 | 1.1129 | 1.5922 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9299.121 | 1.0410 | 1.2046 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9299.121 | 0.9380 | 0.7127 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9299.121 | 0.7830 | 0.1053 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9299.121 | 0.4270 | -0.7457 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9299.121 | 0.1912 | -0.9638 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9299.121 | 0.1456 | -0.9813 | 0.4126 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7825.007 | 0.9175 | 0.8899 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7825.007 | 0.9048 | 0.8726 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7825.007 | 1.0034 | 1.0045 | 1.5199 |