Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 9258.121 | 0.0676 | -0.9927 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 9258.121 | 0.0839 | -0.9885 | 0.4800 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7820.007 | 1.0528 | 1.1562 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7820.007 | 1.0627 | 1.1859 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7820.007 | 1.0818 | 1.2436 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7820.007 | 0.9680 | 0.9071 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7820.007 | 0.8712 | 0.6347 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7820.007 | 0.5759 | -0.1076 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7820.007 | 0.2607 | -0.7201 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7820.007 | 0.2019 | -0.8073 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7820.007 | 0.1898 | -0.8241 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7821.007 | 0.8391 | 0.5474 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7821.007 | 0.8178 | 0.4904 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7821.007 | 0.9228 | 0.7781 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7821.007 | 0.8835 | 0.6687 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7821.007 | 0.8141 | 0.4804 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7821.007 | 0.5476 | -0.1710 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7821.007 | 0.2250 | -0.7742 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7821.007 | 0.1297 | -0.8992 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7821.007 | 0.1309 | -0.8977 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9278.121 | 1.0521 | 1.2389 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9278.121 | 0.9755 | 0.8926 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9278.121 | 1.0112 | 1.0502 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9278.121 | 0.9524 | 0.7945 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9278.121 | 0.9877 | 0.9455 | 0.4498 |