Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 10261.024 | 0.7239 | 0.7250 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 10261.024 | 0.6521 | 0.6444 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 10261.024 | 0.5839 | 0.5633 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 10261.024 | 0.5761 | 0.5537 | 2.1838 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7805.05 | 0.9836 | 0.9726 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7805.05 | 0.9634 | 0.9384 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7805.05 | 1.0334 | 1.0559 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7805.05 | 0.9003 | 0.8316 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7805.05 | 0.9261 | 0.8755 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7805.05 | 0.8876 | 0.8100 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7805.05 | 0.9234 | 0.8709 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7805.05 | 0.8688 | 0.7778 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7805.05 | 0.8254 | 0.7031 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9210.024 | 1.0046 | 1.0106 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9210.024 | 1.0211 | 1.0486 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9210.024 | 0.9977 | 0.9948 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9210.024 | 0.9963 | 0.9915 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9210.024 | 0.9695 | 0.9299 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9210.024 | 0.9752 | 0.9430 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9210.024 | 0.8949 | 0.7603 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9210.024 | 0.8888 | 0.7464 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9210.024 | 0.8277 | 0.6092 | 0.8697 | |
| HBL-100 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.0000427 | uM | 7807.036 | 0.9719 | 0.9727 | 2.0706 | |
| HBL-100 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.000213 | uM | 7807.036 | 0.9733 | 0.9740 | 2.0706 | |
| HBL-100 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.00107 | uM | 7807.036 | 0.9604 | 0.9613 | 2.0706 |