Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7803.036 | 0.5574 | 0.6341 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7803.036 | 0.5737 | 0.6505 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7804.036 | 1.0170 | 1.0135 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7804.036 | 0.9525 | 0.9614 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7804.036 | 0.9772 | 0.9816 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7804.036 | 0.8710 | 0.8925 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7804.036 | 0.8198 | 0.8473 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7804.036 | 0.7266 | 0.7602 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7804.036 | 0.6477 | 0.6811 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7804.036 | 0.6129 | 0.6444 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7804.036 | 0.6699 | 0.7040 | 2.5007 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 9024.05 | 0.9208 | 0.9455 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 9024.05 | 0.9538 | 0.9686 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 9024.05 | 0.8902 | 0.9237 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 9024.05 | 0.7887 | 0.8472 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 9024.05 | 0.7073 | 0.7811 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 9024.05 | 0.6558 | 0.7366 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 9024.05 | 0.5473 | 0.6346 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 9024.05 | 0.5776 | 0.6644 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 9024.05 | 0.5391 | 0.6264 | 2.9873 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 10261.024 | 1.0652 | 1.0587 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 10261.024 | 0.9659 | 0.9685 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 10261.024 | 1.0957 | 1.0855 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 10261.024 | 0.9568 | 0.9599 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 10261.024 | 0.8240 | 0.8303 | 2.1838 |