Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 7527.093 | 0.9425 | 0.9355 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 7527.093 | 0.9779 | 0.9754 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 7527.093 | 0.9996 | 0.9995 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.0213 | uM | 7527.093 | 0.9722 | 0.9691 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.107 | uM | 7527.093 | 0.9730 | 0.9700 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.533 | uM | 7527.093 | 0.9028 | 0.8900 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 2.67 | uM | 7527.093 | 0.8258 | 0.7990 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 13.3 | uM | 7527.093 | 0.7846 | 0.7487 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 66.7 | uM | 7527.093 | 0.8297 | 0.8037 | 1.8070 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.000171 | uM | 10381.093 | 0.9793 | 0.9577 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.000853 | uM | 10381.093 | 1.0279 | 1.0570 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.00427 | uM | 10381.093 | 1.0173 | 1.0354 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.0213 | uM | 10381.093 | 1.0043 | 1.0087 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.107 | uM | 10381.093 | 0.9750 | 0.9491 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.533 | uM | 10381.093 | 0.7969 | 0.5864 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 2.67 | uM | 10381.093 | 0.5255 | 0.0373 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 13.3 | uM | 10381.093 | 0.3060 | -0.4026 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 66.7 | uM | 10381.093 | 0.3347 | -0.3455 | 0.9799 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.000171 | uM | 7530.093 | 1.0015 | 1.0014 | 2.1548 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.000853 | uM | 7530.093 | 1.0302 | 1.0278 | 2.1548 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.00427 | uM | 7530.093 | 1.0350 | 1.0322 | 2.1548 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.0213 | uM | 7530.093 | 1.0294 | 1.0271 | 2.1548 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.107 | uM | 7530.093 | 0.9856 | 0.9865 | 2.1548 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.533 | uM | 7530.093 | 0.8205 | 0.8246 | 2.1548 | |
| SUM149PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 2.67 | uM | 7530.093 | 0.5091 | 0.4621 | 2.1548 |