Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7499.065 | 0.0881 | -0.9774 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7499.065 | 0.0837 | -0.9795 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7500.065 | 0.9598 | 0.9024 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7500.065 | 0.9809 | 0.9536 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7500.065 | 0.9175 | 0.8007 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7500.065 | 0.9013 | 0.7619 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7500.065 | 0.8331 | 0.6007 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7500.065 | 0.4233 | -0.2989 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7500.065 | 0.1134 | -0.8593 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7500.065 | 0.0532 | -0.9441 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7500.065 | 0.0555 | -0.9412 | 0.8201 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7504.065 | 1.0910 | 1.1104 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7504.065 | 1.2703 | 1.3179 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7504.065 | 1.1015 | 1.1228 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7504.065 | 1.1473 | 1.1768 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 7504.065 | 1.1690 | 1.2021 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7504.065 | 0.1295 | -0.4328 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7504.065 | 0.0872 | -0.5555 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7504.065 | 0.0436 | -0.7100 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7504.065 | 0.0056 | -0.9183 | 1.6220 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7506.065 | 1.0132 | 1.0252 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7506.065 | 0.9573 | 0.9185 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7506.065 | 0.9576 | 0.9189 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7506.065 | 0.9742 | 0.9506 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7506.065 | 0.7513 | 0.5221 | 1.0475 |