Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7506.065 | 0.0289 | -0.9322 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7506.065 | 0.0240 | -0.9432 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7506.065 | 0.0275 | -0.9353 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7506.065 | 0.0256 | -0.9395 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7507.065 | 1.0208 | 1.0410 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7507.065 | 0.9579 | 0.9170 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7507.065 | 0.9658 | 0.9326 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7507.065 | 0.9524 | 0.9062 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7507.065 | 0.8035 | 0.6122 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7507.065 | 0.0251 | -0.9470 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7507.065 | 0.0139 | -0.9704 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7507.065 | 0.0155 | -0.9671 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7507.065 | 0.0138 | -0.9707 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7508.065 | 0.9497 | 0.8727 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7508.065 | 0.9819 | 0.9539 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7508.065 | 1.0118 | 1.0301 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7508.065 | 0.8356 | 0.5911 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7508.065 | 0.6107 | 0.0674 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7508.065 | 0.0253 | -0.9815 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7508.065 | 0.0176 | -0.9884 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7508.065 | 0.0197 | -0.9865 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7508.065 | 0.0178 | -0.9882 | 0.7854 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7510.065 | 0.9406 | 0.8284 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7510.065 | 1.0132 | 1.0387 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7510.065 | 1.0043 | 1.0125 | 0.6831 |