Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7510.065 | 0.9400 | 0.8267 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7510.065 | 0.7795 | 0.3889 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7510.065 | 0.3195 | -0.6237 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7510.065 | 0.1570 | -0.8670 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7510.065 | 0.1045 | -0.9267 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7510.065 | 0.0448 | -0.9788 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7511.065 | 0.8727 | 0.7891 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7511.065 | 0.7155 | 0.5207 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7511.065 | 1.0045 | 1.0073 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7511.065 | 0.9664 | 0.9448 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7511.065 | 0.9345 | 0.8920 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7511.065 | 0.3698 | -0.1141 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7511.065 | 0.2515 | -0.3540 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7511.065 | 0.2037 | -0.4563 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7511.065 | 0.0477 | -0.8342 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7512.065 | 0.9886 | 0.9752 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7512.065 | 1.0142 | 1.0310 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7512.065 | 0.9468 | 0.8844 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7512.065 | 0.9901 | 0.9783 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7512.065 | 0.9103 | 0.8052 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7512.065 | 0.5049 | -0.0502 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7512.065 | 0.2409 | -0.5760 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7512.065 | 0.1768 | -0.6974 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7512.065 | 0.1021 | -0.8337 | 0.9176 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7515.065 | 0.8698 | 0.8000 | 1.3234 |