Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7801.012 | 0.9429 | 0.8006 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7801.012 | 1.0062 | 1.0223 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7801.012 | 0.9715 | 0.8994 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7801.012 | 1.0970 | 1.3597 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7801.012 | 0.9587 | 0.8548 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7801.012 | 1.0224 | 1.0808 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7801.012 | 0.9313 | 0.7612 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7801.012 | 0.9623 | 0.8674 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7801.012 | 0.9167 | 0.7121 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7801.036 | 0.9116 | 0.6121 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7801.036 | 0.9676 | 0.8520 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7801.036 | 0.9438 | 0.7479 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7801.036 | 1.0525 | 1.2535 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7801.036 | 0.9307 | 0.6919 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7801.036 | 1.0785 | 1.3849 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7801.036 | 0.9244 | 0.6651 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7801.036 | 0.9683 | 0.8552 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7801.036 | 0.9016 | 0.5708 | 0.4291 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7803.036 | 0.9866 | 0.9907 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7803.036 | 0.9238 | 0.9459 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7803.036 | 0.9161 | 0.9403 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7803.036 | 0.8669 | 0.9037 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7803.036 | 0.7537 | 0.8137 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7803.036 | 0.6995 | 0.7675 | 2.8926 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7803.036 | 0.6235 | 0.6987 | 2.8926 |