Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7793.036 | 0.9903 | 0.9819 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7793.036 | 1.0994 | 1.1845 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7793.036 | 1.0863 | 1.1602 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7793.036 | 1.1519 | 1.2814 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7793.036 | 1.0479 | 1.0891 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7793.036 | 1.0186 | 1.0347 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7793.036 | 0.6074 | 0.2574 | 1.0741 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9157.012 | 1.0288 | 1.0667 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9157.012 | 0.9501 | 0.8850 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9157.012 | 1.0098 | 1.0226 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9157.012 | 0.9885 | 0.9734 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9157.012 | 0.9220 | 0.8207 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9157.012 | 0.9703 | 0.9314 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9157.012 | 0.9627 | 0.9140 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9157.012 | 0.9389 | 0.8593 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9157.012 | 0.9100 | 0.7933 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9163.024 | 1.0513 | 1.1895 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9163.024 | 0.9944 | 0.9798 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9163.024 | 1.0588 | 1.2181 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9163.024 | 1.0628 | 1.2331 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9163.024 | 0.9989 | 0.9959 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9163.024 | 1.0775 | 1.2895 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9163.024 | 0.9740 | 0.9068 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9163.024 | 0.9960 | 0.9854 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9163.024 | 0.9399 | 0.7877 | 0.5524 |