Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 7816.007 | 1.0219 | 1.0379 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7816.007 | 0.8470 | 0.7318 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7816.007 | 0.7229 | 0.5096 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7816.007 | 0.5030 | 0.1025 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7816.007 | 0.4757 | 0.0503 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 7816.007 | 0.2895 | -0.3171 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7816.007 | 0.0973 | -0.7346 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7816.007 | 0.2334 | -0.4335 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7816.007 | 0.1161 | -0.6908 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 9254.121 | 1.0666 | 1.1072 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 9254.121 | 1.0472 | 1.0761 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 9254.121 | 0.8593 | 0.7689 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 9254.121 | 0.4647 | 0.0755 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 9254.121 | 0.4405 | 0.0299 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 9254.121 | 0.3092 | -0.2267 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 9254.121 | 0.1335 | -0.6082 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 9254.121 | 0.1149 | -0.6530 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 9254.121 | 0.1136 | -0.6563 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 9258.121 | 0.8922 | 0.5771 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 9258.121 | 1.0289 | 1.1224 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 9258.121 | 0.7737 | 0.1720 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 9258.121 | 0.4946 | -0.5386 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 9258.121 | 0.4918 | -0.5440 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 9258.121 | 0.3505 | -0.7749 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 9258.121 | 0.0830 | -0.9888 | 0.4800 |