Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 9233.121 | 1.0944 | 1.1998 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 9233.121 | 0.8442 | 0.6724 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 9233.121 | 0.7286 | 0.4315 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.874 | uM | 9233.121 | 0.5745 | 0.1137 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 9233.121 | 0.4652 | -0.1087 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 9233.121 | 0.3383 | -0.3634 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 9233.121 | 0.1822 | -0.6689 | 0.9468 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7812.047 | 1.0374 | 1.0694 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7812.047 | 0.8756 | 0.7679 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7812.047 | 0.9601 | 0.9258 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7812.047 | 1.0766 | 1.1419 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7812.047 | 0.8449 | 0.7105 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7812.047 | 0.4297 | -0.0867 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7812.047 | 0.2098 | -0.5304 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7812.047 | 0.4464 | -0.0538 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7812.047 | 0.4219 | -0.1021 | 1.0776 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 7813.007 | 0.9478 | 0.8758 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7813.007 | 0.9851 | 0.9644 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7813.007 | 0.8855 | 0.7292 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7813.007 | 0.5791 | 0.0407 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7813.007 | 0.5642 | 0.0087 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 7813.007 | 0.4815 | -0.1655 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7813.007 | 0.1576 | -0.7806 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7813.007 | 0.1122 | -0.8539 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7813.007 | 0.1203 | -0.8411 | 0.8361 |