Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9210.121 | 0.9178 | 0.8177 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9210.121 | 0.6277 | 0.1901 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9210.121 | 0.5488 | 0.0245 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9210.121 | 0.4710 | -0.1360 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9210.121 | 0.1874 | -0.6908 | 0.8970 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.000279 | uM | 7808.043 | 1.0311 | 1.0258 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.0014 | uM | 7808.043 | 0.8885 | 0.9035 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.00699 | uM | 7808.043 | 0.7835 | 0.8060 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.0349 | uM | 7808.043 | 0.2832 | 0.1800 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.175 | uM | 7808.043 | 0.0557 | -0.4025 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.873 | uM | 7808.043 | 0.0244 | -0.5766 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 4.37 | uM | 7808.043 | 0.0005 | -0.9165 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 21.8 | uM | 7808.043 | 0.0033 | -0.8173 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 109 | uM | 7808.043 | 0.0078 | -0.7373 | 2.3907 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7810.007 | 1.0668 | 1.1392 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7810.007 | 1.0299 | 1.0622 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7810.007 | 1.0305 | 1.0636 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7810.007 | 0.9328 | 0.8605 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7810.007 | 0.8127 | 0.6121 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7810.007 | 0.5380 | 0.0497 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7810.007 | 0.4091 | -0.2105 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7810.007 | 0.2110 | -0.6034 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7810.007 | 0.1266 | -0.7669 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00028 | uM | 9233.121 | 1.0676 | 1.1431 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 9233.121 | 0.9724 | 0.9417 | 0.9468 |