Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7801.007 | 0.4333 | -0.4535 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7801.007 | 0.2426 | -0.7778 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7801.007 | 0.2713 | -0.7357 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9186.121 | 0.9850 | 0.9641 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9186.121 | 0.9359 | 0.8479 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9186.121 | 0.9455 | 0.8706 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9186.121 | 0.7967 | 0.5249 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9186.121 | 0.6684 | 0.2366 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9186.121 | 0.5688 | 0.0200 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9186.121 | 0.4223 | -0.2852 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9186.121 | 0.3761 | -0.3775 | 0.8379 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9186.121 | 0.3927 | -0.3444 | 0.8379 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 10261.121 | 1.0215 | 1.0190 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 10261.121 | 0.9308 | 0.9374 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 10261.121 | 0.9691 | 0.9724 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 10261.121 | 0.2858 | 0.1474 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 10261.121 | 0.1497 | -0.1389 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 10261.121 | 0.0497 | -0.4718 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 10261.121 | 0.0418 | -0.5108 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 10261.121 | 0.0695 | -0.3874 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 10261.121 | 0.0695 | -0.3874 | 2.2540 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9210.121 | 1.0550 | 1.1230 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9210.121 | 1.0751 | 1.1681 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9210.121 | 0.9358 | 0.8575 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9210.121 | 0.8472 | 0.6624 | 0.8970 |