Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 9386.121 | 0.0809 | -0.7658 | 1.1728 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 7841.077 | 0.9460 | 0.7666 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7841.077 | 1.0269 | 1.1225 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7841.077 | 0.9279 | 0.6920 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7841.077 | 0.9406 | 0.7441 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7841.077 | 0.8979 | 0.5720 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 7841.077 | 0.8252 | 0.3017 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7841.077 | 0.6740 | -0.1719 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7841.077 | 0.4321 | -0.6935 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7841.077 | 0.3273 | -0.8353 | 0.4474 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7849.007 | 1.0404 | 1.1904 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7849.007 | 0.9594 | 0.8185 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7849.007 | 1.0710 | 1.3415 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7849.007 | 0.8265 | 0.2910 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7849.007 | 0.7464 | 0.0214 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7849.007 | 0.6913 | -0.1436 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7849.007 | 0.6053 | -0.3688 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7849.007 | 0.5332 | -0.5283 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7849.007 | 0.4385 | -0.6989 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7849.043 | 1.0108 | 1.0623 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7849.043 | 0.9575 | 0.7668 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7849.043 | 0.9489 | 0.7218 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7849.043 | 1.0541 | 1.3248 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7849.043 | 0.9926 | 0.9582 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7849.043 | 0.9904 | 0.9459 | 0.3502 |