Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7849.043 | 0.8554 | 0.2802 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7849.043 | 0.7752 | -0.0333 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7849.043 | 0.6665 | -0.3722 | 0.3502 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7853.007 | 1.0499 | 1.0742 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7853.007 | 1.0061 | 1.0091 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7853.007 | 0.9864 | 0.9796 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7853.007 | 0.8324 | 0.7432 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7853.007 | 0.7328 | 0.5846 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7853.007 | 0.4808 | 0.1556 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7853.007 | 0.1446 | -0.5301 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7853.007 | 0.0916 | -0.6661 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7853.007 | 0.0703 | -0.7262 | 1.3351 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 9453.121 | 0.9871 | 0.9799 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 9453.121 | 0.9651 | 0.9455 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 9453.121 | 0.6775 | 0.4776 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 9453.121 | 0.1766 | -0.4806 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 9453.121 | 0.0606 | -0.7739 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 9453.121 | 0.0447 | -0.8215 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 9453.121 | 0.0528 | -0.7968 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 9453.121 | 0.0668 | -0.7562 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 9453.121 | 0.0620 | -0.7700 | 1.2860 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 9469.121 | 0.9325 | 0.8800 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 9469.121 | 0.6099 | 0.2911 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 9469.121 | 0.1837 | -0.5537 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 9469.121 | 0.1332 | -0.6641 | 1.1298 |