Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 9469.121 | 0.0840 | -0.7767 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 9469.121 | 0.0715 | -0.8064 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 9469.121 | 0.1039 | -0.7304 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 9469.121 | 0.1234 | -0.6860 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 9469.121 | 0.1168 | -0.7010 | 1.1298 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 10268.007 | 0.9460 | 0.9183 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 10268.007 | 0.9508 | 0.9256 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 10268.007 | 0.4013 | 0.0070 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 10268.007 | 0.1389 | -0.5464 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 10268.007 | 0.4091 | 0.0217 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 10268.007 | 0.0445 | -0.8073 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 10268.007 | 0.0495 | -0.7910 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 10268.007 | 0.0597 | -0.7595 | 1.3306 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 10268.007 | 0.0638 | -0.7471 | 1.3306 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7860.043 | 1.0292 | 1.0784 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7860.043 | 0.9764 | 0.9372 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7860.043 | 0.9912 | 0.9765 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7860.043 | 1.0480 | 1.1292 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7860.043 | 1.0383 | 1.1029 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7860.043 | 0.9959 | 0.9891 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7860.043 | 0.9405 | 0.8426 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7860.043 | 0.9693 | 0.9185 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7860.043 | 0.6598 | 0.1476 | 0.7488 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00028 | uM | 9501.121 | 1.0578 | 1.1641 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 9501.121 | 1.0797 | 1.2274 | 0.7121 |