Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7886.043 | 0.8331 | 0.5353 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7886.043 | 0.5800 | -0.0912 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7886.043 | 0.3749 | -0.5169 | 0.6905 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 7892.043 | 1.0727 | 1.0549 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7892.043 | 0.8782 | 0.9023 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7892.043 | 1.0343 | 1.0262 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7892.043 | 0.9850 | 0.9884 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7892.043 | 0.8287 | 0.8602 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 7892.043 | 0.9215 | 0.9380 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7892.043 | 0.7458 | 0.7862 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7892.043 | 0.7549 | 0.7945 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7892.043 | 0.7556 | 0.7952 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 7893.007 | 1.0428 | 1.0369 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7893.007 | 1.0542 | 1.0466 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7893.007 | 0.9983 | 0.9986 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7893.007 | 0.8844 | 0.8956 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7893.007 | 0.7697 | 0.7841 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 7893.007 | 0.5601 | 0.5529 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7893.007 | 0.3435 | 0.2544 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7893.007 | 0.2083 | 0.0085 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7893.007 | 0.1532 | -0.1181 | 2.2909 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 7505.078 | 0.9831 | 0.9714 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7505.078 | 0.9523 | 0.9191 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7505.078 | 1.0453 | 1.0762 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7505.078 | 0.7872 | 0.6341 | 1.1847 |