Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 0.00107 | uM | 9566.012 | 0.9958 | 0.9963 | 2.2335 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 0.00533 | uM | 9566.012 | 0.7889 | 0.7986 | 2.2335 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 0.0267 | uM | 9566.012 | 0.3222 | 0.2046 | 2.2335 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 0.133 | uM | 9566.012 | 0.2574 | 0.0893 | 2.2335 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 0.667 | uM | 9566.012 | 0.2060 | -0.0141 | 2.2335 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 3.33 | uM | 9566.012 | 0.2026 | -0.0215 | 2.2335 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 16.7 | uM | 9566.012 | 0.2072 | -0.0116 | 2.2335 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7491.05 | 1.0182 | 1.0631 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7491.05 | 0.9322 | 0.7724 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7491.05 | 0.8342 | 0.4642 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7491.05 | 0.5297 | -0.3295 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7491.05 | 0.3367 | -0.6924 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7491.05 | 0.2763 | -0.7810 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7491.05 | 0.3430 | -0.6824 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7491.05 | 0.3333 | -0.6977 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7491.05 | 0.2499 | -0.8158 | 0.5814 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7873.036 | 1.0055 | 1.0055 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7873.036 | 0.9606 | 0.9600 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7873.036 | 0.8897 | 0.8860 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7873.036 | 0.5588 | 0.4931 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7873.036 | 0.3834 | 0.2356 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7873.036 | 0.2971 | 0.0870 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7873.036 | 0.3028 | 0.0974 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7873.036 | 0.3099 | 0.1103 | 1.9906 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7873.036 | 0.2956 | 0.0842 | 1.9906 |