Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7874.05 | 0.9977 | 0.9970 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7874.05 | 1.0413 | 1.0517 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7874.05 | 1.0657 | 1.0818 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7874.05 | 0.9534 | 0.9408 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7874.05 | 0.9520 | 0.9389 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7874.05 | 0.9196 | 0.8971 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7874.05 | 1.0057 | 1.0072 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7874.05 | 0.9651 | 0.9556 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7874.05 | 0.9416 | 0.9256 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7875.012 | 1.0115 | 1.0135 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7875.012 | 0.9635 | 0.9569 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7875.012 | 0.9954 | 0.9946 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7875.012 | 1.0450 | 1.0523 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7875.012 | 0.9700 | 0.9646 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7875.012 | 0.9386 | 0.9272 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7875.012 | 0.9063 | 0.8880 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7875.012 | 0.9012 | 0.8818 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7875.012 | 0.9226 | 0.9078 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9583.012 | 1.0563 | 1.0976 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9583.012 | 0.9953 | 0.9918 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9583.012 | 1.0468 | 1.0812 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9583.012 | 0.9666 | 0.9417 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9583.012 | 0.9784 | 0.9624 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9583.012 | 0.9430 | 0.9003 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9583.012 | 0.9461 | 0.9058 | 1.1482 |