Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7492.074 | 0.9995 | 0.9992 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7492.074 | 1.0033 | 1.0046 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7492.074 | 1.0004 | 1.0005 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7492.074 | 0.9321 | 0.9035 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7492.074 | 0.8729 | 0.8177 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7492.074 | 0.6852 | 0.5332 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7492.074 | 0.4456 | 0.1329 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7492.074 | 0.3232 | -0.0961 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7492.074 | 0.3475 | -0.0488 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7493.074 | 0.9852 | 0.9743 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7493.074 | 0.9876 | 0.9785 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7493.074 | 0.9539 | 0.9199 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7493.074 | 0.9380 | 0.8922 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7493.074 | 0.8389 | 0.7177 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7493.074 | 0.5998 | 0.2847 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7493.074 | 0.3813 | -0.1321 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7493.074 | 0.2947 | -0.3057 | 1.1549 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7493.074 | 0.2501 | -0.3977 | 1.1549 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7494.074 | 0.9773 | 0.9331 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7494.074 | 0.9961 | 0.9885 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7494.074 | 0.9676 | 0.9049 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7494.074 | 0.9431 | 0.8341 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7494.074 | 0.9168 | 0.7591 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7494.074 | 0.8342 | 0.5300 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7494.074 | 0.7858 | 0.4006 | 0.6767 |