Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 3750 | uM | 7486.065 | 0.1919 | -0.5231 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 18700 | uM | 7486.065 | 0.0630 | -0.8187 | 1.1517 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7490.065 | 0.9635 | 0.9702 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7490.065 | 0.9701 | 0.9757 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7490.065 | 0.9906 | 0.9924 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7490.065 | 1.0248 | 1.0198 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7490.065 | 0.9523 | 0.9610 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7490.065 | 0.5463 | 0.5675 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7490.065 | 0.2416 | 0.1283 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7490.065 | 0.0631 | -0.3431 | 2.4816 | |
| MCF12A | NM | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7490.065 | 0.0324 | -0.4977 | 2.4816 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7492.065 | 0.9561 | 0.9448 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7492.065 | 0.9962 | 0.9953 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7492.065 | 1.0117 | 1.0145 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7492.065 | 0.9491 | 0.9360 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7492.065 | 0.8377 | 0.7911 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7492.065 | 0.4512 | 0.2181 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7492.065 | 0.1233 | -0.4572 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7492.065 | 0.1021 | -0.5173 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7492.065 | 0.0679 | -0.6258 | 1.6050 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7493.065 | 0.9608 | 0.9379 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7493.065 | 0.9887 | 0.9821 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7493.065 | 0.9758 | 0.9617 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7493.065 | 1.0310 | 1.0487 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7493.065 | 0.8139 | 0.7003 | 1.2680 |