Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7454.065 | 0.9664 | 0.9359 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7454.065 | 0.8753 | 0.7614 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7454.065 | 0.9589 | 0.9215 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7454.065 | 0.9755 | 0.9533 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7454.065 | 0.9433 | 0.8917 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7454.065 | 0.4419 | -0.0820 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7454.065 | 0.2617 | -0.4429 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7454.065 | 0.0428 | -0.9008 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7454.065 | 0.0173 | -0.9581 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7455.065 | 0.9813 | 0.9785 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7455.065 | 0.9854 | 0.9832 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7455.065 | 0.9775 | 0.9740 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7455.065 | 0.9492 | 0.9411 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7455.065 | 0.8416 | 0.8117 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7455.065 | 0.5540 | 0.4255 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7455.065 | 0.2528 | -0.0909 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7455.065 | 0.0421 | -0.6748 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7455.065 | 0.0146 | -0.8226 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7456.065 | 0.9163 | 0.9140 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7456.065 | 0.9732 | 0.9729 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7456.065 | 0.9712 | 0.9709 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7456.065 | 0.9180 | 0.9158 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7456.065 | 0.8565 | 0.8502 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7456.065 | 0.6208 | 0.5739 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7456.065 | 0.2865 | 0.0671 | 1.9899 |