Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 11851.16 | 0.7095 | 0.4903 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 11851.16 | 0.6722 | 0.4229 | 1.1668 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10875.15 | 1.0194 | 1.0455 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000427 | uM | 10875.15 | 0.9821 | 0.9580 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00213 | uM | 10875.15 | 1.0023 | 1.0053 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0107 | uM | 10875.15 | 0.9511 | 0.8857 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0533 | uM | 10875.15 | 0.9490 | 0.8810 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.267 | uM | 10875.15 | 0.9718 | 0.9341 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 1.33 | uM | 10875.15 | 0.9058 | 0.7808 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 6.67 | uM | 10875.15 | 0.9591 | 0.9043 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 33.3 | uM | 10875.15 | 0.9394 | 0.8585 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000128 | uM | 12428.169 | 1.0762 | 1.1962 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00064 | uM | 12428.169 | 1.0086 | 1.0219 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0032 | uM | 12428.169 | 1.0005 | 1.0013 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.016 | uM | 12428.169 | 1.0324 | 1.0829 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.08 | uM | 12428.169 | 0.9455 | 0.8622 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.4 | uM | 12428.169 | 0.9929 | 0.9819 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 2 | uM | 12428.169 | 0.9712 | 0.9268 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 10 | uM | 12428.169 | 0.9628 | 0.9057 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | ZM-447439 | AURK | AURK | 50 | uM | 12428.169 | 1.0159 | 1.0407 | 0.7851 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10819.15 | 0.9903 | 0.9909 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000427 | uM | 10819.15 | 0.9968 | 0.9970 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00213 | uM | 10819.15 | 0.9668 | 0.9685 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0107 | uM | 10819.15 | 1.0244 | 1.0228 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0533 | uM | 10819.15 | 0.9750 | 0.9763 | 2.1256 |