Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.267 | uM | 10819.15 | 0.9331 | 0.9359 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 1.33 | uM | 10819.15 | 0.9499 | 0.9522 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 6.67 | uM | 10819.15 | 0.9090 | 0.9122 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 33.3 | uM | 10819.15 | 0.8762 | 0.8794 | 2.1256 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000256 | uM | 11937.16 | 0.9847 | 0.9873 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00128 | uM | 11937.16 | 0.9384 | 0.9480 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0064 | uM | 11937.16 | 0.9724 | 0.9769 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.032 | uM | 11937.16 | 0.9483 | 0.9565 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.16 | uM | 11937.16 | 0.9467 | 0.9551 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.8 | uM | 11937.16 | 0.7847 | 0.8089 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 4 | uM | 11937.16 | 0.8061 | 0.8292 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 20 | uM | 11937.16 | 0.4275 | 0.4066 | 2.4144 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 100 | uM | 11937.16 | 0.7480 | 0.7734 | 2.4144 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000256 | uM | 10520.138 | 0.8881 | 0.9298 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00128 | uM | 10520.138 | 1.0850 | 1.0498 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0064 | uM | 10520.138 | 0.9982 | 0.9989 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.032 | uM | 10520.138 | 1.0432 | 1.0257 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.16 | uM | 10520.138 | 0.9942 | 0.9965 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.8 | uM | 10520.138 | 0.4806 | 0.6037 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 4 | uM | 10520.138 | 0.4991 | 0.6221 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 20 | uM | 10520.138 | 0.1853 | 0.2033 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 100 | uM | 10520.138 | 0.3930 | 0.5094 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0000853 | uM | 11057.15 | 0.9780 | 0.9889 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000427 | uM | 11057.15 | 1.0111 | 1.0055 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00213 | uM | 11057.15 | 1.0282 | 1.0139 | 4.0042 |