Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 6.67 | uM | 10694.15 | 0.2048 | -0.0213 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 33.3 | uM | 10694.15 | 0.0073 | -0.7818 | 2.2191 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10816.15 | 1.2988 | 3.7375 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10816.15 | 1.4618 | 5.9987 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10816.15 | 1.2191 | 2.8446 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10816.15 | 1.2570 | 3.2528 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10816.15 | 1.1850 | 2.5010 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10816.15 | 1.3786 | 4.7683 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10816.15 | 1.0809 | 1.5848 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10816.15 | 1.0966 | 1.7113 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10816.15 | 1.1818 | 2.4703 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12319.169 | 0.9077 | 0.8144 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12319.169 | 0.8292 | 0.6567 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12319.169 | 0.8391 | 0.6767 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12319.169 | 0.9930 | 0.9859 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12319.169 | 1.0237 | 1.0477 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12319.169 | 0.9369 | 0.8732 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12319.169 | 0.7992 | 0.5965 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12319.169 | 0.7013 | 0.3999 | 0.9948 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12319.169 | 0.6701 | 0.3374 | 0.9948 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.000128 | uM | 12580.169 | 1.0318 | 1.0293 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.00064 | uM | 12580.169 | 0.9972 | 0.9974 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0032 | uM | 12580.169 | 1.0230 | 1.0212 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.016 | uM | 12580.169 | 1.0064 | 1.0059 | 2.1524 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.08 | uM | 12580.169 | 1.0493 | 1.0452 | 2.1524 |