Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10873.15 | 1.0017 | 1.0029 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000427 | uM | 10873.15 | 0.9772 | 0.9619 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00213 | uM | 10873.15 | 0.9894 | 0.9822 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0107 | uM | 10873.15 | 1.0420 | 1.0699 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0533 | uM | 10873.15 | 1.0591 | 1.0983 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.267 | uM | 10873.15 | 0.9951 | 0.9917 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 1.33 | uM | 10873.15 | 0.6699 | 0.4306 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 6.67 | uM | 10873.15 | 0.6388 | 0.3748 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 33.3 | uM | 10873.15 | 0.5175 | 0.1529 | 1.1958 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000128 | uM | 12400.169 | 0.9385 | 0.9006 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00064 | uM | 12400.169 | 0.9368 | 0.8977 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0032 | uM | 12400.169 | 0.9305 | 0.8876 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.016 | uM | 12400.169 | 0.9277 | 0.8831 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.08 | uM | 12400.169 | 0.9407 | 0.9042 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.4 | uM | 12400.169 | 0.9469 | 0.9142 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 2 | uM | 12400.169 | 0.4987 | 0.1437 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10 | uM | 12400.169 | 0.2512 | -0.3407 | 1.2449 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 50 | uM | 12400.169 | 0.4620 | 0.0756 | 1.2449 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10694.15 | 0.9072 | 0.9141 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000427 | uM | 10694.15 | 0.9548 | 0.9587 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00213 | uM | 10694.15 | 0.9664 | 0.9695 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0107 | uM | 10694.15 | 0.9769 | 0.9790 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0533 | uM | 10694.15 | 0.9871 | 0.9883 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.267 | uM | 10694.15 | 0.9639 | 0.9671 | 2.2191 | |
| Hs 578T | TNBC | Basal B | ZM-447439 | AURK | AURK | 1.33 | uM | 10694.15 | 0.5211 | 0.4909 | 2.2191 |