Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0107 | uM | 11057.15 | 1.1007 | 1.0485 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0533 | uM | 11057.15 | 1.0061 | 1.0030 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.267 | uM | 11057.15 | 0.9422 | 0.9705 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 1.33 | uM | 11057.15 | 0.4078 | 0.5986 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 6.67 | uM | 11057.15 | 0.4509 | 0.6393 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 33.3 | uM | 11057.15 | 0.4425 | 0.6315 | 4.0042 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 12269.16 | 1.0154 | 1.0471 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 12269.16 | 0.9648 | 0.8937 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 12269.16 | 1.1037 | 1.3243 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 12269.16 | 0.9701 | 0.9097 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 12269.16 | 1.0887 | 1.2764 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 12269.16 | 0.9019 | 0.7090 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 12269.16 | 0.9272 | 0.7825 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 12269.16 | 0.9137 | 0.7431 | 0.6567 | |
| SUM185PE | TNBC | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 12269.16 | 0.4735 | -0.3594 | 0.6567 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 10579.138 | 0.9450 | 0.8884 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 10579.138 | 0.9317 | 0.8615 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 10579.138 | 0.8987 | 0.7947 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 10579.138 | 0.9308 | 0.8597 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 10579.138 | 0.9632 | 0.9255 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 10579.138 | 0.9270 | 0.8521 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 10579.138 | 0.7907 | 0.5761 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 10579.138 | 0.6143 | 0.2201 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 10579.138 | 0.8503 | 0.6967 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 12098.16 | 0.8747 | 0.7390 | 0.9575 |