Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7484.065 | 1.0933 | 1.0762 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7484.065 | 1.0550 | 1.0454 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7484.065 | 0.9876 | 0.9895 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7484.065 | 1.0085 | 1.0071 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7484.065 | 1.0070 | 1.0058 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7484.065 | 0.6436 | 0.6627 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7484.065 | 0.2942 | 0.1976 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7484.065 | 0.0339 | -0.5156 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7484.065 | 0.0080 | -0.7361 | 2.3857 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7485.065 | 0.9845 | 0.9913 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7485.065 | 1.0252 | 1.0139 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7485.065 | 1.0359 | 1.0197 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7485.065 | 1.0974 | 1.0525 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7485.065 | 0.9366 | 0.9638 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7485.065 | 0.5849 | 0.7223 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7485.065 | 0.2136 | 0.3006 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7485.065 | 0.0571 | -0.0997 | 3.5869 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7485.065 | 0.0442 | -0.1618 | 3.5869 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 0.048 | uM | 7486.065 | 0.9958 | 0.9927 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 0.24 | uM | 7486.065 | 1.0406 | 1.0703 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 1.2 | uM | 7486.065 | 1.0076 | 1.0132 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 6 | uM | 7486.065 | 1.1348 | 1.2321 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 30 | uM | 7486.065 | 1.1447 | 1.2491 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 150 | uM | 7486.065 | 1.0725 | 1.1252 | 1.1517 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 750 | uM | 7486.065 | 0.7180 | 0.5000 | 1.1517 |