Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 10380.065 | 1.0507 | 1.0675 | 1.4916 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 10380.065 | 1.0407 | 1.0542 | 1.4916 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 10380.065 | 0.9387 | 0.9169 | 1.4916 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 10380.065 | 0.7438 | 0.6400 | 1.4916 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 10380.065 | 0.0909 | -0.5994 | 1.4916 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 10380.065 | 0.0229 | -0.8409 | 1.4916 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 10380.065 | 0.0123 | -0.8951 | 1.4916 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 0.048 | uM | 7482.065 | 0.9650 | 0.9685 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 0.24 | uM | 7482.065 | 0.9984 | 0.9986 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 1.2 | uM | 7482.065 | 0.9932 | 0.9939 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 6 | uM | 7482.065 | 0.9176 | 0.9247 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 30 | uM | 7482.065 | 0.7764 | 0.7863 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 150 | uM | 7482.065 | 0.4436 | 0.3912 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 750 | uM | 7482.065 | 0.1088 | -0.2574 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 3750 | uM | 7482.065 | 0.0251 | -0.6141 | 2.2390 | |
| MB 157 | Unknown | Unknown | Vorinostat | HDAC | HDAC | 18700 | uM | 7482.065 | 0.0112 | -0.7311 | 2.2390 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7483.065 | 1.0145 | 1.0095 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7483.065 | 1.0394 | 1.0255 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7483.065 | 0.9820 | 0.9881 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7483.065 | 0.9777 | 0.9853 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7483.065 | 0.9203 | 0.9462 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7483.065 | 0.4604 | 0.5507 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7483.065 | 0.2020 | 0.1835 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7483.065 | 0.0558 | -0.2238 | 3.0487 | |
| MCF 10A | NM | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7483.065 | 0.0272 | -0.3871 | 3.0487 |