Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7493.065 | 0.4064 | -0.0168 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7493.065 | 0.0858 | -0.7115 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7493.065 | 0.0743 | -0.7427 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7493.065 | 0.0356 | -0.8559 | 1.2680 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7494.065 | 0.9625 | 0.8889 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7494.065 | 0.9653 | 0.8972 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7494.065 | 0.9815 | 0.9448 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7494.065 | 0.9410 | 0.8262 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7494.065 | 0.8615 | 0.6004 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7494.065 | 0.5443 | -0.1944 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7494.065 | 0.2869 | -0.6908 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7494.065 | 0.3178 | -0.6396 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7494.065 | 0.1350 | -0.8999 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 10419.065 | 0.9578 | 0.8861 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 10419.065 | 0.9944 | 0.9848 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 10419.065 | 1.0025 | 1.0067 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 10419.065 | 0.9719 | 0.9240 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 10419.065 | 0.8364 | 0.5688 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 10419.065 | 0.5049 | -0.2098 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 10419.065 | 0.2574 | -0.6837 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 10419.065 | 0.3829 | -0.4574 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 10419.065 | 0.2205 | -0.7437 | 0.7359 | |
| MDA-MB-157 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7495.065 | 0.9860 | 0.9778 | 1.2645 | |
| MDA-MB-157 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7495.065 | 0.9891 | 0.9828 | 1.2645 | |
| MDA-MB-157 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7495.065 | 0.9882 | 0.9814 | 1.2645 |