Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9972.121 | 1.0127 | 1.0229 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9972.121 | 0.9297 | 0.8721 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9972.121 | 0.8423 | 0.7120 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9972.121 | 0.6336 | 0.3226 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9972.121 | 0.5171 | 0.1002 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9972.121 | 0.5054 | 0.0776 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9972.121 | 0.3965 | -0.1352 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9972.121 | 0.1743 | -0.5893 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9972.121 | 0.0583 | -0.8479 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9997.121 | 1.1261 | 1.2254 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9997.121 | 1.0034 | 1.0061 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9997.121 | 0.8975 | 0.8147 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9997.121 | 0.7056 | 0.4617 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9997.121 | 0.6053 | 0.2734 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9997.121 | 0.6055 | 0.2737 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9997.121 | 0.5022 | 0.0766 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9997.121 | 0.1423 | -0.6536 | 1.1121 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9997.121 | 0.0557 | -0.8510 | 1.1121 | |
| 21MT-1 | HER2amp | - | Torkinib | 0.000128 | uM | 15382.211 | 0.9440 | 0.9039 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 0.00064 | uM | 15382.211 | 0.8431 | 0.7288 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 0.0032 | uM | 15382.211 | 0.8070 | 0.6655 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 0.016 | uM | 15382.211 | 0.7133 | 0.4989 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 0.08 | uM | 15382.211 | 0.5418 | 0.1853 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 0.4 | uM | 15382.211 | 0.4612 | 0.0330 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 2 | uM | 15382.211 | 0.3970 | -0.0910 | 1.1714 |