Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21MT-1 | HER2amp | - | Torkinib | 10 | uM | 15382.211 | 0.3253 | -0.2333 | 1.1714 | |||
| 21MT-1 | HER2amp | - | Torkinib | 50 | uM | 15382.211 | 0.3100 | -0.2640 | 1.1714 | |||
| 21NT | HER2amp | - | Torkinib | 0.000128 | uM | 15383.211 | 0.9556 | 0.9141 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 0.00064 | uM | 15383.211 | 0.8826 | 0.7724 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 0.0032 | uM | 15383.211 | 0.8187 | 0.6482 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 0.016 | uM | 15383.211 | 0.7783 | 0.5695 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 0.08 | uM | 15383.211 | 0.6647 | 0.3475 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 0.4 | uM | 15383.211 | 0.5979 | 0.2162 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 2 | uM | 15383.211 | 0.5634 | 0.1483 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 10 | uM | 15383.211 | 0.4993 | 0.0217 | 1.0341 | |||
| 21NT | HER2amp | - | Torkinib | 50 | uM | 15383.211 | 0.4779 | -0.0206 | 1.0341 | |||
| AU565 | HER2amp | Luminal | Torkinib | 0.000128 | uM | 15384.211 | 0.9185 | 0.8748 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 0.00064 | uM | 15384.211 | 0.7129 | 0.5466 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 0.0032 | uM | 15384.211 | 0.6159 | 0.3839 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 0.016 | uM | 15384.211 | 0.4307 | 0.0546 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 0.08 | uM | 15384.211 | 0.3320 | -0.1347 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 0.4 | uM | 15384.211 | 0.2956 | -0.2077 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 2 | uM | 15384.211 | 0.2707 | -0.2590 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 10 | uM | 15384.211 | 0.2374 | -0.3294 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Torkinib | 50 | uM | 15384.211 | 0.2072 | -0.3952 | 1.3162 | |||
| BT-20 | TNBC | Basal A | Torkinib | 0.000128 | uM | 15385.211 | 0.8021 | 0.4799 | 0.7321 | |||
| BT-20 | TNBC | Basal A | Torkinib | 0.00064 | uM | 15385.211 | 0.6946 | 0.2158 | 0.7321 | |||
| BT-20 | TNBC | Basal A | Torkinib | 0.0032 | uM | 15385.211 | 0.6669 | 0.1501 | 0.7321 | |||
| BT-20 | TNBC | Basal A | Torkinib | 0.016 | uM | 15385.211 | 0.6047 | 0.0060 | 0.7321 | |||
| BT-20 | TNBC | Basal A | Torkinib | 0.08 | uM | 15385.211 | 0.4761 | -0.2742 | 0.7321 |