Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 7899.077 | 1.0383 | 1.0346 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7899.077 | 0.7891 | 0.7952 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7899.077 | 0.8488 | 0.8559 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7899.077 | 0.4141 | 0.3378 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7899.077 | 0.3729 | 0.2753 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 7899.077 | 0.3139 | 0.1790 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7899.077 | 0.3331 | 0.2114 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7899.077 | 0.3111 | 0.1742 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7899.077 | 0.1338 | -0.2010 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 10266.121 | 1.2291 | 1.6732 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 10266.121 | 0.8567 | 0.6091 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 10266.121 | 1.2515 | 1.7421 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 10266.121 | 0.5870 | -0.0547 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 10266.121 | 0.4746 | -0.2988 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 10266.121 | 0.3568 | -0.5306 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 10266.121 | 0.3839 | -0.4797 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 10266.121 | 0.3822 | -0.4830 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 10266.121 | 0.2560 | -0.7058 | 0.7110 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9708.121 | 0.9657 | 0.9396 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 9708.121 | 1.0289 | 1.0506 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9708.121 | 1.0249 | 1.0437 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 9708.121 | 0.8545 | 0.7423 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 9708.121 | 0.5654 | 0.2125 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9708.121 | 0.3154 | -0.2736 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9708.121 | 0.2655 | -0.3754 | 1.1394 |