Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 9501.121 | 1.0157 | 1.0443 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 9501.121 | 1.0154 | 1.0433 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 9501.121 | 0.9800 | 0.9440 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.874 | uM | 9501.121 | 0.6361 | 0.0596 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 9501.121 | 0.0798 | -0.9426 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 9501.121 | 0.0461 | -0.9735 | 0.7121 | |
| HCC70 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 9501.121 | 0.0297 | -0.9857 | 0.7121 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.000279 | uM | 7911.007 | 1.0453 | 1.0579 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.0014 | uM | 7911.007 | 0.9670 | 0.9573 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.00699 | uM | 7911.007 | 1.1025 | 1.1295 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.0349 | uM | 7911.007 | 0.9387 | 0.9203 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.175 | uM | 7911.007 | 0.9359 | 0.9166 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.873 | uM | 7911.007 | 0.8978 | 0.8660 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 4.37 | uM | 7911.007 | 0.8222 | 0.7634 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 21.8 | uM | 7911.007 | 0.7657 | 0.6845 | 1.5549 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 109 | uM | 7911.007 | 0.2669 | -0.1449 | 1.5549 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 7863.007 | 1.0528 | 1.0718 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7863.007 | 1.0206 | 1.0282 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7863.007 | 1.0076 | 1.0104 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7863.007 | 1.0010 | 1.0014 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7863.007 | 0.9041 | 0.8663 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 7863.007 | 0.9038 | 0.8659 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7863.007 | 0.7465 | 0.6366 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7863.007 | 0.7355 | 0.6200 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7863.007 | 0.3935 | 0.0548 | 1.4578 |