Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 10264.121 | 1.0645 | 1.0938 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 10264.121 | 0.9050 | 0.8588 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 10264.121 | 0.9760 | 0.9646 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 10264.121 | 0.7778 | 0.6636 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 10264.121 | 0.7494 | 0.6188 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 10264.121 | 0.6120 | 0.3954 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 10264.121 | 0.3014 | -0.1697 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 10264.121 | 0.2064 | -0.3709 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 10264.121 | 0.2081 | -0.3671 | 1.3643 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.00028 | uM | 9039.078 | 0.9371 | 0.8041 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.0014 | uM | 9039.078 | 0.9559 | 0.8621 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.00699 | uM | 9039.078 | 0.8397 | 0.5160 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.0349 | uM | 9039.078 | 0.6996 | 0.1350 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.175 | uM | 9039.078 | 0.2793 | -0.7353 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 0.874 | uM | 9039.078 | 0.0461 | -0.9848 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 4.37 | uM | 9039.078 | 0.0139 | -0.9977 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 21.8 | uM | 9039.078 | 0.0196 | -0.9961 | 0.6306 | |
| MB 157 | Unknown | Unknown | Topotecan | TOP1 | TOP | 109 | uM | 9039.078 | 0.0169 | -0.9969 | 0.6306 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.000279 | uM | 7870.007 | 0.9849 | 0.9853 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7870.007 | 0.9002 | 0.9010 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7870.007 | 0.7873 | 0.7819 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7870.007 | 0.6711 | 0.6497 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7870.007 | 0.4988 | 0.4295 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.873 | uM | 7870.007 | 0.2243 | -0.0282 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7870.007 | 0.0247 | -0.6648 | 2.0710 |