Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7870.007 | 0.0119 | -0.7644 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7870.007 | 0.0104 | -0.7793 | 2.0710 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 9551.121 | 1.0052 | 1.0038 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 9551.121 | 0.9041 | 0.9278 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 9551.121 | 0.9386 | 0.9543 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 9551.121 | 0.5279 | 0.5842 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 9551.121 | 0.4609 | 0.5078 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 9551.121 | 0.2161 | 0.1438 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 9551.121 | 0.0713 | -0.2367 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 9551.121 | 0.0157 | -0.5607 | 2.7416 | |
| MCF 10A | NM | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 9551.121 | 0.0103 | -0.6234 | 2.7416 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.00028 | uM | 7488.078 | 0.9711 | 0.9616 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.0014 | uM | 7488.078 | 0.9283 | 0.9040 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.00699 | uM | 7488.078 | 0.8042 | 0.7317 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.0349 | uM | 7488.078 | 0.6305 | 0.4744 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.175 | uM | 7488.078 | 0.5337 | 0.3207 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.874 | uM | 7488.078 | 0.3506 | 0.0004 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 4.37 | uM | 7488.078 | 0.2510 | -0.1979 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 21.8 | uM | 7488.078 | 0.0920 | -0.5867 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 109 | uM | 7488.078 | 0.0486 | -0.7292 | 1.5130 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.000279 | uM | 7872.007 | 0.9984 | 0.9981 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.0014 | uM | 7872.007 | 0.8922 | 0.8711 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.00699 | uM | 7872.007 | 0.8680 | 0.8413 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.0349 | uM | 7872.007 | 0.7891 | 0.7417 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.175 | uM | 7872.007 | 0.7024 | 0.6272 | 1.7126 |