Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.873 | uM | 7872.007 | 0.4420 | 0.2416 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 4.37 | uM | 7872.007 | 0.3140 | 0.0168 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 21.8 | uM | 7872.007 | 0.0705 | -0.5750 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 109 | uM | 7872.007 | 0.3404 | 0.0660 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.00028 | uM | 9566.121 | 1.0531 | 1.0454 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.0014 | uM | 9566.121 | 0.9088 | 0.9189 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.00699 | uM | 9566.121 | 0.9889 | 0.9903 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.0349 | uM | 9566.121 | 0.7192 | 0.7339 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.175 | uM | 9566.121 | 0.6037 | 0.6073 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 0.874 | uM | 9566.121 | 0.4227 | 0.3774 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 4.37 | uM | 9566.121 | 0.2934 | 0.1760 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 21.8 | uM | 9566.121 | 0.1069 | -0.2405 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 109 | uM | 9566.121 | 0.0213 | -0.6225 | 2.3089 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 7491.078 | 0.9465 | 0.8536 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7491.078 | 0.8712 | 0.6532 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7491.078 | 0.8123 | 0.5008 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7491.078 | 0.6960 | 0.2122 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7491.078 | 0.5824 | -0.0523 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 7491.078 | 0.3318 | -0.5643 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7491.078 | 0.0261 | -0.9870 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7491.078 | 0.0113 | -0.9959 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7491.078 | 0.0099 | -0.9966 | 0.7238 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 10061.121 | 0.9797 | 0.9789 | 1.9364 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 10061.121 | 0.9640 | 0.9625 | 1.9364 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 10061.121 | 0.8936 | 0.8871 | 1.9364 |