Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7832.036 | 0.8534 | 0.7673 | 1.2817 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7832.036 | 0.7653 | 0.6234 | 1.2817 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7832.036 | 0.7200 | 0.5478 | 1.2817 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7832.036 | 0.8119 | 0.6998 | 1.2817 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7833.05 | 0.9997 | 0.9994 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7833.05 | 0.9963 | 0.9936 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7833.05 | 0.9814 | 0.9676 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7833.05 | 0.8941 | 0.8149 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7833.05 | 0.9027 | 0.8300 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7833.05 | 0.8489 | 0.7349 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7833.05 | 0.7309 | 0.5236 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7833.05 | 0.8056 | 0.6579 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7833.05 | 0.7995 | 0.6470 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7834.05 | 0.9291 | 0.9242 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7834.05 | 1.0050 | 1.0053 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7834.05 | 0.8909 | 0.8822 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7834.05 | 0.8791 | 0.8690 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7834.05 | 0.8299 | 0.8133 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7834.05 | 0.8424 | 0.8276 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7834.05 | 0.8094 | 0.7897 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7834.05 | 0.7397 | 0.7069 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7834.05 | 0.6741 | 0.6256 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 10262.012 | 1.0566 | 1.1991 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 10262.012 | 1.0268 | 1.0932 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 10262.012 | 0.9803 | 0.9325 | 0.5802 |