Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 10262.012 | 0.8879 | 0.6294 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 10262.012 | 0.9008 | 0.6705 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 10262.012 | 0.9152 | 0.7166 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 10262.012 | 0.9773 | 0.9225 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 10262.012 | 0.9448 | 0.8136 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 10262.012 | 0.7653 | 0.2614 | 0.5802 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7836.05 | 1.0945 | 1.1259 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7836.05 | 0.9609 | 0.9468 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7836.05 | 1.0211 | 1.0285 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7836.05 | 0.8335 | 0.7683 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7836.05 | 0.8645 | 0.8125 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7836.05 | 0.7574 | 0.6574 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7836.05 | 0.7493 | 0.6453 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7836.05 | 0.6597 | 0.5097 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7836.05 | 0.6412 | 0.4809 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7837.05 | 1.0398 | 1.0459 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7837.05 | 0.8551 | 0.8258 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7837.05 | 1.0853 | 1.0977 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7837.05 | 0.7458 | 0.6860 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7837.05 | 0.7797 | 0.7302 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7837.05 | 0.5846 | 0.4631 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7837.05 | 0.6182 | 0.5114 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7837.05 | 0.5877 | 0.4675 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7837.05 | 0.3766 | 0.1324 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7839.05 | 1.1012 | 1.1134 | 1.7470 |