Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7877.05 | 0.5732 | -0.2727 | 0.5502 | |
| MDA-MB-134-VI | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7877.05 | 0.3648 | -0.6800 | 0.5502 | |
| MDA-MB-134-VI | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7877.05 | 0.4499 | -0.5316 | 0.5502 | |
| MDA-MB-134-VI | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7877.05 | 0.4995 | -0.4337 | 0.5502 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 10093.012 | 0.9819 | 0.9639 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 10093.012 | 0.5772 | 0.1584 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 10093.012 | 0.9621 | 0.9248 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 10093.012 | 0.6494 | 0.3024 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 10093.012 | 0.8220 | 0.6461 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 10093.012 | 0.7350 | 0.4728 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 10093.012 | 0.6970 | 0.3972 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 10093.012 | 0.7835 | 0.5693 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 10093.012 | 0.6963 | 0.3958 | 1.0064 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7884.05 | 1.0271 | 1.1431 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7884.05 | 1.0026 | 1.0133 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7884.05 | 1.0437 | 1.2338 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7884.05 | 0.9516 | 0.7591 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7884.05 | 0.7869 | 0.0766 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7884.05 | 0.6569 | -0.3250 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7884.05 | 0.5608 | -0.5515 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7884.05 | 0.5116 | -0.6463 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7884.05 | 0.5168 | -0.6369 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7885.05 | 0.9562 | 0.8672 | 0.6518 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7885.05 | 0.9482 | 0.8434 | 0.6518 | |
| MDA-MB-175-VII | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7885.05 | 0.9225 | 0.7671 | 0.6518 |