Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 0.0107 | uM | 7504.074 | 1.2024 | 1.2041 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 0.0533 | uM | 7504.074 | 1.0876 | 1.0906 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 0.267 | uM | 7504.074 | 0.9305 | 0.9255 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 1.33 | uM | 7504.074 | 0.9930 | 0.9927 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 6.67 | uM | 7504.074 | 0.7767 | 0.7504 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 33.3 | uM | 7504.074 | 0.6223 | 0.5573 | 1.8962 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7506.074 | 0.9989 | 0.9982 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7506.074 | 1.0046 | 1.0076 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7506.074 | 0.9681 | 0.9477 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7506.074 | 0.9173 | 0.8637 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7506.074 | 0.9825 | 0.9713 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7506.074 | 0.8277 | 0.7135 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7506.074 | 0.8202 | 0.7008 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7506.074 | 0.7161 | 0.5221 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7506.074 | 0.7514 | 0.5831 | 1.2231 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7507.074 | 0.9547 | 0.8919 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.000427 | uM | 7507.074 | 1.0260 | 1.0626 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.00213 | uM | 7507.074 | 0.9829 | 0.9592 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0107 | uM | 7507.074 | 0.9935 | 0.9844 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0533 | uM | 7507.074 | 0.9284 | 0.8295 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.267 | uM | 7507.074 | 0.9441 | 0.8668 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 1.33 | uM | 7507.074 | 0.9148 | 0.7975 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 6.67 | uM | 7507.074 | 0.8100 | 0.5535 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 33.3 | uM | 7507.074 | 0.7577 | 0.4340 | 0.8342 | |
| MDA-MB-361 | HER2amp | Luminal | Triciribine | AKT | AKT | 0.0000853 | uM | 7508.074 | 0.9600 | 0.8996 | 0.7924 |