Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10579.14 | 0.2114 | -0.6237 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12098.159 | 1.0027 | 1.0052 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12098.159 | 1.0554 | 1.1078 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12098.159 | 1.0340 | 1.0662 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12098.159 | 1.1335 | 1.2597 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12098.159 | 1.0612 | 1.1192 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12098.159 | 0.9655 | 0.9327 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12098.159 | 0.4815 | -0.0190 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12098.159 | 0.3465 | -0.2880 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12098.159 | 0.2049 | -0.5733 | 1.0261 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 11058.152 | 0.9694 | 0.9703 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11058.152 | 1.0367 | 1.0350 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11058.152 | 1.0270 | 1.0258 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11058.152 | 1.0833 | 1.0784 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11058.152 | 0.9952 | 0.9954 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11058.152 | 0.9765 | 0.9773 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11058.152 | 0.5719 | 0.5290 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11058.152 | 0.2962 | 0.1146 | 2.0809 | |
| SUM229PE | TNBC | - | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11058.152 | 0.2581 | 0.0432 | 2.0809 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10695.152 | 1.0376 | 1.0600 | 1.2495 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10695.152 | 0.9982 | 0.9971 | 1.2495 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10695.152 | 0.9769 | 0.9629 | 1.2495 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10695.152 | 1.0156 | 1.0249 | 1.2495 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10695.152 | 0.9931 | 0.9889 | 1.2495 | |
| SUM52PE | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10695.152 | 0.8397 | 0.7390 | 1.2495 |