Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11057.152 | 1.0221 | 1.0114 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11057.152 | 1.0239 | 1.0123 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11057.152 | 1.0410 | 1.0209 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11057.152 | 1.0508 | 1.0259 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11057.152 | 1.0035 | 1.0018 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11057.152 | 0.2369 | 0.3765 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11057.152 | 0.0829 | 0.0480 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11057.152 | 0.0702 | 0.0039 | 3.8541 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12269.152 | 1.0149 | 1.0340 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12269.152 | 1.0304 | 1.0694 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12269.152 | 1.1290 | 1.2959 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12269.152 | 1.0713 | 1.1629 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12269.152 | 0.9333 | 0.8490 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12269.152 | 0.5697 | 0.0546 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12269.152 | 0.4331 | -0.2281 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12269.152 | 0.2220 | -0.6390 | 0.8791 | |
| SUM185PE | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12269.152 | 0.1451 | -0.7774 | 0.8791 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10579.14 | 1.0049 | 1.0105 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 10579.14 | 0.9777 | 0.9520 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 10579.14 | 0.9921 | 0.9831 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10579.14 | 1.0734 | 1.1582 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10579.14 | 1.0113 | 1.0243 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10579.14 | 0.9503 | 0.8934 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10579.14 | 0.6595 | 0.2785 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10579.14 | 0.3326 | -0.3875 | 0.9303 |